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Causal Link Between Periodontal Disease and Alzheimer’s Disease?

The recent study by a team of doctors at NYU led by Dr Angela Kramer found fresh evidence that gingivitis could lead to neurodegeneration and Alzheimer’s disease. The team examined 20 years of data which supposts the hypothesis of a possible causal link between periodontal disease and Alzheimer’s disease. Dr Kramer said that:” The research suggests that cognitively normal subjects with periodontal inflammation are at an increased risk of lower cognitive function compared to cognitively normal subjects with little or no periodontal inflammation

The study found that subjects with Alzheimer’s disease has unusually higher levels of inflammatory cytokines and antibodies associated with periodontal disease as compare to healthy subjects. The research team compared the cognitive function at age 50 and 70 using a Digital Symbol Test which is used to measure the adult IQ. The resuls showed that the subjects with periodontal inflammation had nine times more likely to test in the lower range of DST score as compared to subjects with little or no periodontal inflammation. The finding were presented at the recently concluded IADR meeting in Spain.

Adapted from Science Daily

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