Tuesday

Gingival Overgrowth!

Basic science expalnation of gingival overgrowth: ( from the Oral Biology class by Dr Garant)
  • Cyclosporine A ( CsA) has been shown to decrease the expression of α2β1 integrin, a receptor involved in binding collagen fibrils in the early stage of pahgocytosis. Thus csA decreases the internal pathway of collagen resorption. Collagen accumulates in the gingival tissue.
  • CsA and Ca++ chanel blockers reduce internal Ca++ thereby reducing the binding affinity of α2β1 for collagen.
  • Dilatin and cyclosporin decrease cathepsins needed for degredation of collagen inside phagosomes.
  • Both TGF-β and FGF are elevated in the enlarged gingiva. TGF-β promotes synthesis of collagen, FGFs promote fibroblast proliferation.

1 comment:

Anonymous said...

Good update Dr.Joshi.
Srinivas

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