Genetic Links Between periodontitis and chronic heart disease.

A recent study found genetic link between periodontitis and chronic heart disease (CHD). The geman scientists who found this quoted that both disease share atleast one genetic risk factor but its not necessary that the person who has periodontitis develops CHD.Both these disease share the same loci on the chromosome but exhibit opposite phenotypes ( 1,2).

Points to be noted: There is strong genetic link between periodontitis and CHD.
They share the same locus , but since the phenotypes are diffrent, they may have diffrent genetics, so one variant may have increased risk for periodontitis while other varian may have risk for CHD.
So patients with periodontitis should take more preventive steps and try reduce their risk factors for CHD.

Refrences:
1)Periodontitis and CHD: First Evidence of a Genetic Link
2)Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis

Being a dentist in Australia

I found out some information for those of you who are looking to study in Australia. This article briefly highlights about the necessities of going through to become a licensed dentist in Australia. Read about to become a dentist in Australia here.

In another article you can read the details about the Australian Dentistry Association

Phorphynomonas gingivalis in News Again

Phorphynomonas gingivalis has recently been in news again! One of the reason that brought P. gingivaalis into news again was the findings of the research from Nihon University Japan. They found out that P. gingivalis strongly facilitated the reactivation of HIV-1 by high production of butyric acid. This study showed that P. gingivalis could act as a risk factor for HIV-1 in latently infected individuals (1).

Another study in smokers also got P.gingivalis into focus. In smokers the cigarette smoke is found to alter some of the genes of P. gingivalis associated with its virulence, detoxification, DNA repair, and oxidative stress mechanism. This results in changes with protein expression in the cell membrane, which affects the bacterial cell characteristics and how immune system recognizes it. These results could possibly explain why smokers are resistant to periodontal treatment and are more susceptible to oral disease caused by P. gingivalis.

References:

1.IADR2009, abstract #1703, "Reactivation of Latent HIV-1 by
Porphyromonas gingivalis Involves Histone Modifcation", by K. Ochiai
et al., of Nihon University, Tokyo, Japan

2. Tobacco-induced alterations to Porphyromonas gingivalis–host interactions
http://www3.interscience.wiley.com/journal/121659253/abstract

Perio Talk is back up and working!

Hello readers, Perio Talk is all up and working fine again. Sorry with the accessibility issues with the site last week.
I will soon be updating you about the recent happenings in the Periodontal research.

Change in domain Url ( temporary)

Hello readers, Since I am transferring my domain to another registrar the perio-talk.com wont be available for few days. Instead you will have to use perio-blog.blogspot.com to access this site. Sorry for the trouble, when things are back to normal I will be notifying it here again.

Thank you.

More Antibiotics for Periodontal Treatment. To use or not to use?

The literature about periodontal micro flora till date is not complete as most of the studies till date have explored the disease causing bacteria. Only few studies have actually tried to explore the health associated bacteria and even with these studies the limitations in the bio techniques have given us incomplete data. I read a recent news about a group coming out with narroe spectrun atibiotics which is supposed to target only the diease causing bacteria and leaving the health associated bacteria intact. My question is " with linited knowledge of the health associated bacteria in the oral cavity and it possible intreactions, using such drugs is really beneficial??"

Here is what the Prof Brogden from Univ of Iowa has to say:
"We are developing an antibiotic that can target and kill a particular pathogen without harming or altering the composition of the normal, more beneficial bacteria in the body. Such a product would provide a variety of new treatments for oral diseases as well as a means of prevention."

Prof Brogden attached a broad sepctrumantibiotic to a protein that targets the specific receptor on the cell wall of the bacteria. When this narrow spectrum antibiotic was tried on a mix of bacteria, it only killed P. gingivalis, whicle leaving the other to bacteria as it is.

Certainly P.gingivalis is known to be involved in periodontal disease but I imagine that out knowledge about oral bacteria and their interactions needs to be better understood brfore we attempt to nuke our mouth with antibiotics, which have their own set of side effects.

Any comments and dicussion on this topic is welcome.

Adapted from Scientific Daily ( from http://www.sciencedaily.com­ /releases/2009/04/090401200431.htm)

Inspektor TC- Visualizing Plaque at Home!

It would be so nice if we could visualize the plaque with our eyes so that we could target those specific areas as we brush daily. Dentist do use disclosing solutions but they often stain or have unpleasant taste.

Inspektor TC is a new product on the block which makes this task of visualizing plaque easier. This tooth sized wand has a blue light at its tip. When shown around the mouth and viewed through yellow glasses, plaque glows bright red against the yellow teeth. This can be routinely used at home by patients for better plaque control, especially those who are prone to gum disease and cavities.

This was created by a team at University of Liverpool. This is what Professor Sue Higham Unversity's S chool of Dental Sciences has to say "It is extremely difficult to get rid of all plaque in the mouth. Left undisturbed it becomes what we call ‘mature’ plaque and gets thicker. This is what leads to gingivitis, or bleeding gums, and decay.

“Early stage plaque is invisible, and so this device will show people the parts of the mouth hey are neglecting when they brush their teeth, enabling them to remove plaque before it becomes a problem.

“Inspektor TC is designed so that people can easily incorporate it into their daily dental hygiene routine at home".

This seems like quite a practical device to use especially in the present times when periodontal disease and dental cavities are prevalent at such high percentage in our society.

Sources: University of Liverpool Press Release, Liverpool Daily Post

Periodontology Text books for Free- Online.

Periodontology textbooks by Carranza and Lindhe are such books every dental student and professional would like to own. If you are of the kind who want to read their textbooks of from your computer then you can download these textbooks from here.

Carranza's Clinical Periodontology (9th Edition)

Download Link Here

Clinical periodontology and Implant Dentistry (4th Edition) Jan Lindhe

Download Link Here

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Check Out This Free Textbook of Dental Hygiene and Therapy-

se of
Here is a book on Clinical dental Hygiene which will help all the students of dentistry and as reference material for the professionals.
You can download the textbook from either of the links given below.
Clinical textbook of Dental Hygiene and Therapy:

Download Link1

Download Link2


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